Dr. Wayne L. Hynes

Associate Professor of Biological Sciences
Track Coordinator, Biomedical Sciences
Director, Master's Degree Programs in Biological Sciences

Hynes, W.L. 2004. Extracellular virulence factors of group A streptococci and their regulation. (Review article). Frontiers in Bioscience. 9: 3399-3433

Ceraul, S.M., D.E. Sonenshine, R.E. Ratzlaff and W. L. Hynes. 2003. An arthropod defensin expressed by the hemocytes of the American dog tick, Dermacentor variabilis (Acari: Ixodidae). Insect Biochem. Mol. Biol. 33: 1099-1103

Sonenshine, D.E., S. Ceraul, W.L. Hynes, K. Macaluso, and A. Azad. 2002. Expression of defensin-like peptides in tick hemolymph and midgut in response to challenge with Borrelia burgdorferi, Escherichia coli, and Bacillus subtilis. Proceedings of the 4th Internation Conference on Ticks and Tick-borne Pathogens. Alberta, Canada. Exp. Appl. Acarology. 28: 127-134

Ceraul, S.M., D.E. Sonenshine, and W.L. Hynes. 2002. Resistance of the tick, Dermacentor variabilis (Acari: Ixodidae) following challenge with the bacterium, Escherichia coli (Enterobacteriales: Enterobacteriaceae). J. Med. Ent. 39: 376 - 383

Broadwater, A.H., D.E. Sonenshine, W.L. Hynes, S. Ceraul, and A.M. deSilva. 2002. Glass capillary tube feeding: a method for infecting nymphal Ixodes scapularis (Acari: Ixodidae) with the Lyme disease spirochete Borrelia burgdorferi. J. Med. Ent. 39: 285 - 292

Johns, R.H., D.E. Sonenshine & W.L. Hynes. 2001. Identification of a defensin from the hemolymph of the American dog tick, Dermacentor variabilis. Insect Biochem. Mol. Biol. 31: 857 - 865

Johns, R., J. Ohnishi, A. Broadwater, D.E. Sonenshine, A. deSilva, & W.L. Hynes. 2001. Contrasts in tick immune responses to Borrelia burgdorferi challenge: immunotolerance in Ixodes scapularis (L.) versus immunocompetence in Dermacentor variabilis. J. Med. Ent. 38: 99 - 107

Johns, R., S. Ceraul, D. Sonenshine, and W. Hynes. 2001. Tick immunity to microbial infections: control of representative bacteria in the hard tick, Dermacentor variabilis (say)(Acari: Ixodidae). pp 638 - 644 In: Acarology Proceedings of the 10th International Congress (Halliday, R.B., D. E. Walter, H.C. Proctor, R.A. Norton and M.J. Colloff eds) CSIRO Publishing, Melbourne, Australia.

Johns, R.H., D.E. Sonenshine & W.L. Hynes. 2000. Enhancement of OspC expression by Borrelia burgdorferi in the presence of tick hemolymph. FEMS Microbiol. Lett. 193: 137-141.

Johns, R., D. Sonenshine, and W. Hynes. 2000. Response of the tick Dermacentor variabilis (Acari: Ixodidae) to hemocoelic inoculation of Borrelia burgdorferi (Spirochetales). J. Med. Ent. 37: 265-270

Hynes, W.L. and S. Walton. 2000. Hyaluronidases of Gram-Positive Bacteria. FEMS Microbiol. Lett. 183: 201 - 207.

Hynes, W.L., A.R. Dixon, S. Walton, and L.J. Aridgides. 2000. The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes. FEMS Microbiol. Lett. 184: 109-112.

McLaughlin, R.E., J.J. Ferretti, and W.L. Hynes. 1999. Nucleotide sequence of the streptococcin A-FF22 lantibiotic regulon: model for production of the lantibiotic SA-FF22 by strains of Streptococcus pyogenes. FEMS Microbiol. Lett. 175: 171 - 177

Johns, R., D. Sonenshine, and W. Hynes. 1998. Control of bacterial infections in the hard tick, Dermacentor variabilis (Acari: Ixodidae); evidence for the existence of antimicrobial proteins in tick hemolymph. J. Medical Entomology 35: 458 - 464

Hynes, W.L., L. Hancock and J.J. Ferretti. 1995. Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: Evidence for a third hyaluronidase involved in extracellular enzymatic activity. Infect. Immun. 63: 3015-3020

Hynes, W.L. and J.J. Ferretti. 1995. A response regulator gene controls production of the lantibiotic streptococcin A-FF22. In: Genetics of Streptococci, Enterococci and Lactococci (Ferretti, J.J., M.S. Gilmore, T.R. Klaenhammer, and F. Brown eds.). Proceedings of the IVth International Conference on Streptococcal Genetics. Dev. Biol. Stand. Basel, Kager. 85: 635 - 637

Hynes, W.L., H. Malke and J.J. Ferretti. 1994. Expression of a kringle-streptokinase fusion protein in baculovirus-infected insect cells. In: Pathogenic Streptococci: Present and Future Proceedings of the XIIth Lancefield International Symposium on Streptococci and Streptococcal Diseases. (Totolian, A. ed.) pp. 185-186. Lancer Publications, St. Petersburg, Russia.

Hynes, W.L. & J.J. Ferretti. 1994. Assays for Hyaluronidase Activity. In: Methods in Enzymology. Vol. 235 Bacterial Pathogenesis (Clark, V.L. and Bavoil, P.M. eds.). pp. 606-616. Academic Press, Inc., Orlando, FL.

Hynes, W.L. V.L. Friend & J.J. Ferretti. 1994. Duplication of the structural gene in M-type 49 strains of group A streptococci producing streptococcin A-M49. Appl. Environ. Microbiol. 60: 4207-4209

Hynes, W.L., J.J. Ferretti & J.R. Tagg. 1993. Cloning of the gene encoding streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence. Appl. Environ. Microbiol. 59: 1969-1971

Hynes, W.L., J.J. Ferretti, M.S. Gilmore and R. A Segarra. 1992. PCR amplification of streptococcal DNA using crude cell lysates. FEMS Microbiol. Lett. 94: 139-142.

Ferretti, J.J., T.-T. Huang, W.L. Hynes, H. Malke, D. Simon, A. Suvorov & C.E. Yu. 1991. Extracellular product genes of group A streptococci. In: Genetics of Streptococci, Lactococci and Enterococci (Dunny, G.M., P.P. Cleary and L.L. McKay eds.) pp. 201-205. A.S.M. Washington, D.C.

Hynes, W.L. & J.J. Ferretti. 1989. Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A. Infect. Immun. 57: 533-539.

Ferretti, J.J., C.E. Yu, W.L. Hynes & C.R. Weeks. 1987. Molecular characterization of the group A streptococcal exotoxin type A (erythrogenic toxin) gene and product. In: Streptococcal Genetics (Ferretti, J.J. & R. Curtiss III, eds.) pp. 130-135. A.S.M. Washington, D.C.

Hynes, W.L. & J.J. Ferretti. 1987. Cloning of the hyaluronidase gene from Streptococcus pyogenes bacteriophage H4489A. In: Streptococcal Genetics (Ferretti, J.J. & R. Curtiss III, eds.) pp. 150-152. A.S.M. Washington, D.C.

Hynes, W.L., C.R. Weeks, J.J. Iandolo & J.J. Ferretti. 1987. Immunologic cross-reactivity of type A streptococcal exotoxin (erythrogenic toxin) and staphylococcal enterotoxins B and C1. Infect. Immun. 55: 837-838.

Hynes, W.L. & J.R. Tagg. 1986. Proteinase-related broad-spectrum inhibitory activity among group A streptococci. J. Med. Microbiol. 22: 257-264.

Hynes, W.L. & J.R. Tagg. 1986. Role of proteinase in the formation of inhibitory levels of hematin by group A streptococcus cultures on blood-containing media. J. Clin. Microbiol. 23:929-933.

Hynes, W.L. & J.R. Tagg. 1985. A simple plate assay for detection of group A streptococcus proteinase. J. Microbiol. Methods 4: 25-31.

Hynes, W.L. & J.R. Tagg. 1985. Production of broad-spectrum bacteriocin-like activity by group A streptococci of particular M-types. Zbl. Bakt. Hyg. A. 259: 155-164

Hynes, W.L. & J.R. Tagg. 1984. Bacteriocin-like activity produced by an M-type 25 group A streptococcus. Proc. Univ. Otago Med. Sch. 62: 109-110.*

Wong, H.K., J.R. Tagg & W.L. Hynes. 1981. Bacteriocin-like inhibitors of group A streptococci produced by group F and G streptococci. Proc. Univ. Otago Med. Sch. 59: 105-106.*