Old Dominion University
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College of Sciences

Department of Biological Sciences

Dr. Barbara Y. Hargrave

Associate Professor of Biological Sciences, Old Dominion University
Adjunct Assistant Professor of Physiology, Eastern Virginia Medical School


Doctor of Philosophy, 1985

Teaching Responsibilities:

Biol 424/524, Animal Physiology
Biol 493/593, Human Neurophysiology
Biol 716/816, Endocrinology
Advanced Cardiovascular Physiology (BIMD)

Research Interests:

My major goal has been to determine mechanisms available to the developing fetus for maintaining volume homeostasis. We have concentrated on the angiotensin-aldosterone system in the developing fetus. In addition, we are studying the effects of drugs such as cocaine and heroin on the renin-angiotensin-aldosterone and cardiovascular systems of the developing fetus. We are also doing work on etiological factors in Persistent Pulmonary Hypertension in the neonate.

Selected Publications:

Hargrave, B. Y., and M. C. Castle. Effects of phenylephrine induced increase in arterial pressure and closure of the Ductus Arteriosus on the secretion of atrial natruiretic peptide (ANP) and renin in the ovine fetus. Life Sciences 57: 31-43, 1995.

Hargrave, B. Y., and M. C. Castle. Intrauterine exposure to cocaine increased plasma ANP (Atrial Natruiretic Peptide), but did not alter hypoxanthine concentrations in the sheep fetus. Life Sciences 56: 1689-1697, 1995.

Contact Information:

Department of Biological Sciences Old Dominion University
Norfolk, VA 23529-0266
Phone: (757) 683-3595
Fax: (757) 683-5283
e-mail: bhargrav@odu.edu