Dr. Christopher J. Osgood
Associate Professor of Biological Sciences
Postdoctoral training in Genetics, 1980
University of California-Davis
Ph.D. Biology, 1977
B.A. Human Biology, 1971
Biology 507, Molecular and Immunological Techniques
Biology 523, Cellular and Molecular Biology
Biology 755, Molecular Genetics
Research interests in my lab fall into three areas: nanotechnology, bioinformatics and bioelectrics. Work in nanotechnology currently focuses on impacts of nanoparticles on developing zebrafish embryos. We wish to determine whether nanoparticles induce cell death and developmental abnormality and to understand the mechanisms whereby such damage is induced. Chemical genetics describes an emerging field in biology where chemically induced effects on development are correlated with specific genetic controls. Chemicals become conditional alleles in this analogy and offer an efficient way to understand how nanomaterials impact early development. Work on this project is supported by the National Science Foundation, and is carried out in collaboration with Dr X. Nancy Xu in our Dept. of Chemistry and Biochemistry. Bioinformatics describes the conjunction of computational approaches to answer complex questions in biology. Among the areas of greatest interest in modern bioinformatics is the nature of protein-protein interaction networks, and how those networks are altered in response to challenges including pathogen attack. Working with colleagues in Computer Science and at Eastern Virginia Medical School, we are currently developing a pilot program to catalog interactions between viral and human proteins for key human viruses. We will not only systematically discover those interactions, both through digital library and wet lab approaches, but we will also develop a visualization tool that will allow biologists to quickly assess what is known about viral-human protein interactions and how those proteins are connected. This work is supported by pilot project funds from the ODU Office of Research. Bioelectrics investigates the effects of electrical fields on biological systems and finds applications in such areas as wound healing and in treatment of solid tumors. Working with investigators at the Frank Reiddy Center for Bioelectrics, we are investigating the mechanism(s) whereby ultrashort electrical pulses are able effectively to kill melanoma cells. Our efforts focus specifically on DNA repair and the ability of ultrashort pulses to induce DNA damage and thereby destroy tumor cells. Melanoma cells appear to be more sensitive to DNA damage induction and we would like to understand the basis for that sensitivity.
Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, XN Xu. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1:133-43, 2007.
Schoenbach KH, Hargrave B, Joshi RP, Kolb JF, Nuccitelli R, Osgood C et al. Bioelectric effects of intense nanosecond pulses. IEEE Transactions on Dielectrics and Electrical Insulation 14(5):1088-1109, 2007
Mitchell RD, Ross E, Osgood C, Sonenshine DE, Donohue KV, Khalil SM, Thompson M,Roe M. Molecular characterization, tissue-specific expression and RNAi knockdown of the first vitellogenin receptor from a tick. Insect Biochem Molec Biol 2007, 37(4):375-88
Thompson DM, Sayed M, Khalil S, Jeffers LA, Sonenshine DE, Mitchell RD, Osgood CJ, Roe MR. Sequence and the developmental and tissue-specific regulation of the first vitellogenin messenger RNA from ticks responsible for heme sequestration. Insect Biochem Molec Biol 2007, 37(4):363-74
Maly K, Pothen A, Zubair M, Osgood C, Semmes OJ. A prototype of the Human Virus Interactome Resource (HVIR). RCDL Sept 2006, pp172-80, Vladimir Russia.
Lattanzio FA, Tiangco D, Osgood C, Beebe S, Kerry J, Hargrave BY. Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria and activates genes associated with heart failure and remodeling. Cardiovasc Toxicol 2005 5(4):377-90.
Tiangco DA, Lattanzio FA, Osgood CJ, Beebe SJ, Kerry JA, Hargrave BY. 3,4-Methylendioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells. Cardiovasc Toxicol 2005; 5(3):301-10.
Thompson DM, Khalil SM, Jeffers LA, Ananthapadmanaban U, Sonenshine DE, Mitchell RD, Osgood CJ, Apperson CS, Roe MR. In vivo role of 20-hydroxyecdysone in the regulation of the vitellogenin mRNA and egg development in the American dog tick, Dermocentor variabilis (Say). J Insect Physiol 2005; 51(10):1105-16.
Ramadan E, Osgood C, Pothen A. The architecture of a proteomic network in the Yeast. Proceedings of CompLife 2005, Lecture Notes in Bioinformatics, 2005; 3695:265-76.
Yamaguchi H, Aridgides LJ, Zeng W, Osgood C, Young NS, Liu JM. Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients. Blood Cells Mol Dis 2003; 30(3):307-11.
My collaborator in nano/biotechnology is Dr X Nancy Xu.
The Frank Reidy Center for Bioelectrics.
The Center for Computational Sciences and Bioinformatics at ODU, headed by Dr Alex Pothen.
I'm interested in bioinformatics and interact regularly with colleagues in Computer Science.
I am an adjunct faculty member in the Dept. of Pediatrics at EVMS, and have laboratory space at the Center for Pediatric Research.
The Department of Biological Sciences has an excellent animal care facility that can be used by investigators from other institutions.
March of Dimes Disaster Preparedness Conference, 2008
Department of Biological Sciences Old Dominion University
Norfolk, VA 23529-0266
Phone: (757) 683-3605
Fax: (757) 683-5283