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College of Sciences


Department of Biological Sciences




Dr. R. James Swanson

University Professor
Professor of Biological Sciences
Director, Mouse Embryo Development & Gross Anatomy Laboratories

Education:

B.S.N. Nursing, 1985
Old Dominion University

Ph.D. Biological Sciences, 1976
Florida State University

M.S. Exercise Physiology, 1972
Florida State University

B.S. Physical Education, Minor in Biology, 1969
Wheaton College

Teaching Responsibilities:

Biol 716/816, Endocrinology
Biol 763/863, Research Science Small Animal Surgery
Biol 789/889, Gross Human Anatomy
Biol 790/890, Advanced Physiology
Biol 791/891, Advanced Physiology Laboratory

Research Interests:

1. mechanism of mammalian ovulation using a rabbit model
2. gamete interaction and early embryo development using a mouse model
3. ROS, antioxidant enzymes, and hypoxia in human sperm function
4. light- and electron- microscopic morphologic evaluation of human spermatozoa
5. Nanosecond electric pulses (nsEP) of biological tissues
6. Melanoma cancer and nsEP

Selected Publications:

Swanson RJ, Serebrovska Z. Intermittent Hypoxia Remedies Male Subfertility. In: Intermittent Hypoxia and Human Diseases. Ed. Xi L, Serebrovskaya TV, Springer, 2012, p 221-228. Available on line at: [http://www.springerlink.com/content/978-1-4471-2905-9/#section=1078989&page=1]

Bocca S, Anderson S, Amaker B, Swanson RJ, Franchi A, Oehninger S. Milk Fat Globule Epidermal Growth Factor 8 (MFG-E8): a novel protein in the mammalian endometrium with putative roles in implantation and placentation. Placenta, Accepted June 19, 2012, Manuscript PL-11-90149R1

Butler, MJ IV, Heisig-Mitchell J, MacDiarmid AB, and Swanson RJ. The Effect of Male Size and Spermatophore Characteristics on Reproduction in the Caribbean Spiny Lobster. Panulirus argus. New Frontiers in Crustacean Biology, 2011, 15:69-84

Chen X, Chen X, Schoenbach KH, Zheng S, Swanson RJ. Comparative study of long- and short-pulsed electric fields for treating melanoma in an in vivo mouse model. In Vivo, 2011, 25(1):23-27.

Chen X, Chen X, Swanson RJ, Schoenbach KH, Yin S, Zheng S. Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF). Journal of Dermatological Treatment, 2011, 22(3):153-61

Chen XH, Kolb JF, Swanson RJ, Schoenbach KH, Beebe SJ. Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields. Pigment Cell and Melanoma Research, 2010, 23(4):554-563.

Swanson RJ, Bowman A, Xiao S, Tan P, Pakhomov A and Schoenbach K. High-Voltage (HV) Nanosecond Pulsed Electric Fields (nsPEFs) Induce Muscular Facilitation and Inhibition in Rats. Joint Meeting of the Bioelectromagnetics Society (BEMS) and the European BioElectromagnetics Association (EBEA), BioEM2009, Davos, Switzerland, June 18, 2009 (available online only).

Chen X, Swanson RJ, Kolb J, Schoenbach KH. Histopathology of Normal Skin and Melanomas after Nanosecond Pulsed Electric Field (nsPEF) Treatment. Melanoma Research, 2009, 19(6):361-371.

Simsek-Duran F, Li F, Ford W, Swanson RJ, Jones Jr. HW and Castora FJ. The effect of aging on the metabolic function and structure of mitochondria in Hamster oocytes FASEB Journal, 2009, 855:10-16.

Nuccitelli R, Chen X, Pakhomov A, Baldwin W, Sheikh S, Pomicter J, Ren W, Osgood C, Swanson RJ, Kolb J, Beebe S, Schoenbach K. A New Pulsed Electric Field Therapy for Melanoma Disrupts the Tumor's Blood Supply and Causes Complete Remission without Recurrence. International Journal of Cancer, 2009, 125:438-445.

Vaamonde D, Da Silva-Grigoletto ME, Garcia-Manso JM, Vaamonde-Lemos R, Swanson RJ, Oehninger SC. Response of Semen Parameters to Three Training Modalities. Fertility and Sterility, 2009, 92(6):1941-1946.

Swanson RJ, Zhang Y, Sonenshine D, Osgood C, Beebe S, Schoenbach KH. Hatching and death rates of nematode Caenorhabditis elegans post-nanosecond pulsed electric fields (nsPEF) (Nematoda). Journal of Morphology, 2008, 269:1496-97.

Vaamonde D, Da Silva-Grigoletto ME, Swanson RJ, Garcia-Manso JM, Suarez-Serra R, Oehninger SC. Alterations of sperm morphology among practitioners of three different training modalities. Fertility and Sterility, Suppl, 2009, 90:S495-S496.

Castora FJ, Simsek-Duran F, Li F, Wyatt K, Swanson RJ, and Jones HW, Jr. Age-associated Morphologic and Metabolic Changes in Mouse and Hamster Oocyte Mitochondria. Molecular Biology of the Cell, Suppl, 2008, 19:2296-2302.

Kolb JF, Mohamed A-A H, Price RO, Swanson RJ, Bowman A, Chiavarini RL, Stacey M, and Schoenbach KH. Cold Atmospheric Pressure Air Plasma Jet for Medical Applications. Applied Physics Letters, 2008, 92(24):1501.

Chen N, Garner AL, Chen G, Jing Y, Ding Y, Swanson RJ, Kolb JF, Beebe SJ, Joshi RP, Schoenbach KH. Nanosecond Electric Pulses Penetrate the Nucleus and Enhance Speckle Formation. Biochemical and Biophysical Research Communications, 2007, 364(2):220-25.

Schoenbach KH, Hargrave B, Joshi RP, Kolb JF, Osgood C, Nuccitelli R, Pakhomov A, Stacey M, Swanson RJ, White JA, Xiao S, Zhang J, Beebe SJ, Blackmore PF, Buescher ES. Bioelectric Effects of Intense Nanosecond Pulses. Institute of Electrical and Electronics Engineers, Transactions on Dielectrics and Electrical Insulation (IEEE-TDEI) 2007,14(5):1088-1109.

Swanson RJ, Chen X, Nuccitelli R, Beebe SJ, Pliquett U, Ford W, Kolb JF, Zheng S, Schoenbach KH. Melanoma Morphology Change & Apoptosis Induced by Multiple Nanosecond Pulsed Electric Fields. Electromagnetics in Advanced Applications. ICEAA 2007. International Conference on Electromagnetics in Advanced Applications, 10th Annual Conference Proceedings published online in IEEE Xplore, Digital Object Identifier: 10.1109/ICEAA.2007.4387486 2007.10:1036-1039.

R. Menkveld, E. E. Oettle, T. F. Kruger, R. J. Swanson, A. A. Acosta, S. Oehninger. Atlas of Human Sperm Morphology. Baltimore: Williams & Wilkins, 1991. (121 pages)

R. J. Swanson. "Flow Cytometry in Evaluating Human Spermatozoa for Clinical Treatment in Reproductive Problems" in Esterilidade e Intertilidade Humana, Ed. Mariangela Badalotti, Editora Medsi, Porto Alegre, Portugal, November, 1996.

M. H. Mitchell, R. J. Swanson, G. D. Hodgen, S. Oehninger. Enhancement of in vitro murine embryo development by recombinant leukemia inhibitory factor. Journal of Society for Gynecologic Investigation 1994, 1(3): 215-219.

R. J. Swanson, M. G. Leavitt. Fertilization and mouse embryo development in the presence of Midazolam. Anesthesia and Analgesia 1992, 75(4): 549-554.

R. J. Swanson, I. Gorpinchenko, N. Boyko, A. Pershukov, Z. Serebrovskaya, T. Serebrovskaya. Tissue analysis report on seventeen testicular biopsies taken from Kiev Urology and Nephrology Research Institute patients eight years after the Chernobyl accident. Second Ukranian Congress of Pathophysiologists, (1996 annual meeting, October 9-11, 1996) Kiev, Ukraine.

Menkveld R, Oettlé EE, Kruger TF, Swanson RJ, Acosta AA, Oehninger S.  Atlas of Human Sperm Morphology.  Baltimore:  Williams & Wilkins, 1991. (121 pages)

Acosta AA, Swanson RJ, Ackerman SB, Kruger TF, Van Zyl JA, Menkveld R (editors).  Human Spermatozoa in Assisted Reproduction.  Baltimore:  Williams & Wilkins, 1990.  (388 pages)

McDowell J, Swanson RJ, Maloney M, Veeck L.  Mouse embryo quality control for toxicity determination in the Norfolk in vitro fertilization program.  Journal of In Vitro Fertilization and Embryo Transfer 1988, 5(3):144-8.

Oehninger SC, Acosta AA, Toner JP, Swanson RJ, Coddington CC, Kruger TF, Franken DR, Hodgen GD.  Sperm-zona pellucida binding:  Predicting fertilizing potential of human gametes by hemizona assay.  Assisted Reproductive Technology/Andrology 1992, 3:1-14.

Swanson RJ, Taylor, SL, Oehninger, s. Mouse embryo development during incubation under low-level hydrogen peroxide culture conditions.  Fertility and Sterility 1997, 1997(1):120-121.

Mitchell MH, Swanson RJ, Hodgen GD, Oehninger.  Enhancement of in vitro Murine embryo development by recombinant leukemia inhibitory factor.  Journal of Society for Gynecologic Investigation 1994, 1(3):215-19.

Oehninger S, Mahony MC, Swanson RJ, Hodgen GD.  The specificity of human spermatozoa/zona pellucida interaction under hemizona assay conditions.  Molecular Reproduction and Development 1993, 35:57-61.

Swanson RJ, Leavitt MG.  Fertilization and mouse embryo development in the presence of midazolam.  Anesthesia and Analgesia 1992, 75(4):549-554.

Mitchell MH, Swanson RJ, Oehninger S.  In vivo effect of leukemia inhibitory factor (LIF) and an anti-LIF polyclonal antibody on murine embryo and fetal development following exposure at the time of transcervical blastocyst transfer.  Biology of Reproduction 2002, 67:460-464.

Swanson RJ, Chen X, Nuccitelli R, Beebe SJ, Pliquett U, Ford W, Kolb JF, Zheng S, Schoenbach KH. Melanoma Morphology Change & Apoptosis Induced by Multiple Nanosecond Pulsed Electric Fields. Electromagnetics in Advanced Applications. ICEAA 2007. International Conference on Electromagnetics in Advanced Applications, 10th Annual Conference Proceedings published online in IEEE Xplore, Digital Object Identifier: 10.1109/ICEAA.2007.4387486 2007.10:1036-1039.

Chen X, Swanson RJ, Beebe SJ, Zheng S, Kolb JF, Schoenbach KH.  Nanosecond Pulsed Electric Fields (nsPEFs) Inhibit Melanoma Angiogenesis. International Conference on Electromagnetics in Advanced Applications, 10th Annual Conference Proceedings published online in IEEE Xplore [http://ieeexplore.ieee.org/xpl/RecentCon.jsp?punumber =4387205] (2007).

Swanson RJ, Chen X, Nuccitelli R.  Nanosecond Pulsed Electric Fields (nsPEFs) Caused Down Regulation in Melanoma B16-F10 Tumors on SKH-1 Mice. Bioelectromagnetics Society (BEMS), 29th Annual Conference Proceedings, 2007, pp 289-95.

Chen X, Swanson RJ, Nuccitelli R.  Nanosecond Pulsed Electric Fields (nsPEFs) Inhibit B16-F10 Melanoma Tumors by Enhancing Apoptosis and Reducing Angiogenesis. 4-4 (The Curtis Carl Johnson Memorial Award Winner Paper) Bioelectromagnetics Society (BEMS), 29th Annual Conference Proceedings, 2007, pp 295-302.

Jeng HA, Swanson RJ.  Toxicity of Metal Oxide Nanoparticles in Mammalian Cells.  Journal of Environmental Science and Health, Part A:  Toxic/Hazardous Substance & Environmental Engineering 2006, A 41(12):46-51.

Nuccitelli R, Pliquett U, Chen X, Ford W, Swanson RJ, Beebe SJ, Kolb JF, Schoenbach KH.  Nanosecond pulsed electric fields cause melanomas to self-destruct.  Biochemical and Biophysical Research Communications 2006, 343(2):351-360.

Van Opdorp H, Van Lunen BL, Swanson RJ.  Fracture of the superomedial weight-bearing surface of the acetabulum in a division I field hockey player:  A case study.  Journal of Sport Rehabilitation 2004, 13(4):343-352.

Mahony MC, Alexander NJ, Swanson RJ.  Evaluation of semen parameters by means of automated sperm motion analyzers.  Fertility and Sterility 1988, 49:876 880.

Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S.  Predictive value of abnormal sperm morphology in in vitro fertilization. Fertility and Sterility 1988, 49:112 117.

Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Veeck LL, Morshedi M, Brugo S.  New method of evaluating sperm morphology with predictive value for human in vitro fertilization.  Urology 1987, 30:248 251.

Kruger TF, Ackerman S, Simmons KF, Swanson RJ, Brugo S, Acosta A.  A quick reliable staining technique for sperm morphology.  Archives of Andrology 1987, 18:275-278.

Acosta AA, Chillik CC, Brugo S, Ackerman S, Swanson RJ, Pleban P, Yuan J, Haque D.  In vitro fertilization and the male factor.  Urology 1986, 28:1 8.

Ackerman S, Swanson RJ, Stokes G, Veeck L.  Culture of mouse preimplantation embryos as a quality control assay for human in vitro fertilization.  Gamete Research, 1984, 9:(2) 145 152.

Swanson RJ, Mayer JF, Jones KH, Lanzendorf SE, McDowell J.  Hamster ova/human sperm penetration assay correlated with count, motility, and morphology for in vitro fertilization. Archives of Andrology, 1984, 12:(supplement)  69 77.

Ackerman SB, Taylor SP, Swanson RJ, Laurel LH.  Mouse embryo culture for screening in human IVF.  Archives of Andrology, 1984, 12:(supplement) 129 136.

Swanson RJ, Ackerman S.  Zona pellucida free hamster ova/human sperm in vitro interaction as an indicator of oolemma penetrating ability.  Infertility, 1983, 6:(1 4) 287 292.

Ackerman SB, Swanson RJ.  In vitro fertilization and preimplantation embryo development in mice.  Infertility, 1983, 6:(1 4) 293 298.

Contact Information:

Department of Biological Sciences Old Dominion University
Norfolk, VA 23529-0266
Phone: (757) 683-3614
Fax: (757) 683-5283
e-mail: jswanson@odu.edu