Dr. Lesley H. Greene

Assistant Professor

Education::

Ph.D. in Biochemistry, University of Miami, Florida 1998
B.S. in Microbiology, University of Miami, Florida, 1991

Research Interests::

The question "how does an amino acid sequence encode a proteins corresponding three-dimensional structure?", also known as "the second-half of the genetic code", remains one of the most fundamental and unresolved problems in science today. The main goal of Dr. Greene's research is to elucidate the critical determinants governing protein evolution, structure, stability and folding. From an evolutionary perspective, her research group has endeavored to identify and study conserved features which she proposes are key to resolving this problem. Her research is hypothesis driven and her approach has been to combine computational and experimental methodologies in one unified effort.

The computational research involves the development and application of bioinformatics, molecular dynamics simulations and network principles to form the basis for hypotheses development and to facilitate the interpretation of experimental results. Her experimental approach utilizes modern methods in molecular biology and protein engineering as well as a range of state-of-the-art biophysical techniques including stopped-flow fluorescence, circular dichroism and nuclear magnetic resonance spectroscopy. She is committed to fostering creativity and to training our future scientists.

Location:

Office: Alfriend Chemistry Building Room 202
Laboratory: Alfriend Chemistry Building Rooms 205 and 209

Contact Information:

Dr. Lesley Greene
Department of Chemistry and Biochemistry
Old Dominion University
4541 Hampton Boulevard
Norfolk, Virginia 23529-0126

Office phone: 757-683-6596

Laboratory phone: 757-683-4086
Fax number: 757-683-4628

e-mail: lgreene@odu.edu