Dr. Wayne L. Hynes

Associate Professor of Biological Sciences
Track Coordinator, Biomedical Sciences
Director, Master's Degree Programs in Biological Sciences

Education:

Bachelor of Science (Honors) (Biology), Otago University, Dunedin, New Zealand. 1981

Doctor of Philosophy (Microbiology), Otago University, Dunedin, New Zealand. 1985

Teaching Responsibilities:

BIOL 315, General Microbiology
BIOL 407/507, Molecular and Immunological Techniques
BIOL 430/530, Microbial Pathogenesis
BIOL 705/805, Advanced Microbiology
BIOL 730/830, Emerging Infectious Diseases

Research Interests:

The major areas of my research in progress at the moment, and which will be the focus for myself and students over the next few years are (1) examination of the innate immune system of the hard ticks, in particular Dermacentor variabilis and Ixodes scapularis by defining the gene, tissue of production and regulation of the defensins; in addition we are looking for addition antimicrobial agents associated with the innate immune response, (2) understanding the virulence of S. pyogenes, in particular the role of the streptococcal hyaluronate lyase by examining regulation, serotype association, protein analysis and secretion mechanisms, site-directed mutagenesis and animal models of infection, and (3) antibiotic resistance genes in Vibrio cholerae transported in ship ballast water. A brief outline of these research areas is described.

• INNATE IMMUNITY
• STREPTOCOCCAL HYALURONATE LYASE
• ANTIBIOTIC RESISTANCE IN BALLAST WATER
• OTHER PROJECTS

Selected Publications:

Hynes, W.L. 2004. Extracellular virulence factors of group A streptococci and their regulation. (Review article). Frontiers in Bioscience. 9: 3399-3433

Ceraul, S.M., D.E. Sonenshine, R.E. Ratzlaff and W. L. Hynes. 2003. An arthropod defensin expressed by the hemocytes of the American dog tick, Dermacentor variabilis (Acari: Ixodidae). Insect Biochem. Mol. Biol. 33: 1099-1103

Sonenshine, D.E., S. Ceraul, W.L. Hynes, K. Macaluso, and A. Azad. 2002. Expression of defensin-like peptides in tick hemolymph and midgut in response to challenge with Borrelia burgdorferi, Escherichia coli, and Bacillus subtilis. Proceedings of the 4th Internation Conference on Ticks and Tick-borne Pathogens. Alberta, Canada. Exp. Appl. Acarology. 28: 127-134

Ceraul, S.M., D.E. Sonenshine, and W.L. Hynes. 2002. Resistance of the tick, Dermacentor variabilis (Acari: Ixodidae) following challenge with the bacterium, Escherichia coli (Enterobacteriales: Enterobacteriaceae). J. Med. Ent. 39: 376 - 383

Broadwater, A.H., D.E. Sonenshine, W.L. Hynes, S. Ceraul, and A.M. deSilva. 2002. Glass capillary tube feeding: a method for infecting nymphal Ixodes scapularis (Acari: Ixodidae) with the Lyme disease spirochete Borrelia burgdorferi. J. Med. Ent. 39: 285 - 292

Johns, R.H., D.E. Sonenshine & W.L. Hynes. 2001. Identification of a defensin from the hemolymph of the American dog tick, Dermacentor variabilis. Insect Biochem. Mol. Biol. 31: 857 - 865

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