Dr. Wayne L. Hynes
Professor of Biological Sciences, Chair
Bachelor of Science (Honors) (Biology), Otago University, Dunedin, New Zealand. 1981
Doctor of Philosophy (Microbiology), Otago University, Dunedin, New Zealand. 1985
BIOL 315, General Microbiology
BIOL 430/530, Microbial Pathogenesis
Biol 672, Responsible Conduct of Research
BIOL 730/830, Emerging Infectious Diseases
The major areas of my research in progress at the moment, and which will be the focus for myself and students over the next few years are (1) continuing the examination of ticks and tick-borne diseases that occur in SE Virginia and extending these studies to other areas of the state, (2) what happens when vector ticks infected with one bacteria come in contact with another pathogen, (3) examination of the innate immune system of the hard ticks, by defining the gene, tissue of production and regulation of the defensins; in addition we are looking for addition antimicrobial agents associated with the innate immune response, (4) understanding the virulence of S. pyogenes, in particular the role of the streptococcal hyaluronate lyase by examining regulation, serotype association, protein analysis and secretion mechanisms, site-directed mutagenesis and animal models of infection. A brief outline of these research areas is described.
Hynes, W.L. 2012. How ticks control microbes: innate immune responses. In Biology of Ticks (Sonenshine, D.E. and R.M. Roe eds). Oxford University Press, NY. In Press.
Luce-Fedrow, A., C. Wright, H. Gaff, D. Sonenshine, W. Hynes, A Richards. 2012.In vitro propagation of Candidatus Rickettsia andeanae isolated from Amblyomma maculatum. FEMS Immunol. & Med Microbiol. 64: 74-81 doi: 10.1111/j.1574-695X.2011.00905.x
Nadolny, R.M., C. L. Wright, W. L. Hynes, D. E. Sonenshine & H. D. Gaff. 2011. Ixodes affinis (Acari: Ixodidae) in southeastern Virginia and implications for the spread of Borrelia burgdorferi, the agent of Lyme disease. J.Vector Ecology. 36: 464-467 doi: 10.1111/j.1948-7134.2011.00191.x
Wright, C.L., R. M. Nadolny, J. Jiang, A. L. Richards, D. E. Sonenshine, H. D. Gaff, W. L. Hynes. 2011. Rickettsia parkeri in Gulf Coast ticks, Southeastern Virginia, USA. Emerging Infectious Diseases. 17: 896-898. doi: 10.3201/eid1705.101836
Laroussi, M., E, Karakas, & W. Hynes. 2011. Influence of Cell Type, Initial Concentration, and Medium on the Inactivation Efficiency of Low-Temperature Plasma. IEEE Transact Plasma Sci. 39: 2960-2961. doi: 10.1109/TPS.2011.2143731
Hynes, W., C. Johnson and M Stokes. 2009. A single nucleotide mutation results in loss of enzymatic activity in the hyaluronate lyase gene of Streptococcus pyogenes . Microbial Pathogenesis. In Press.
Hynes, W. L., M. M. Stokes, S. M Hensley, S. M. Todd, and D. E. Sonenshine. (2008) Using RNA interference to determine the role of Varisin in the innate immune system of the hard tick Dermacentor variabilis (Acari: Ixodidae). Exp. Appl. Acarol. 46: 7-15
Sonenshine, D.E. and W.L. Hynes. 2008. Molecular characterization and related aspects of the innate immune response in ticks. Front. Biosci. 13: 7046-7063
W.L. Hynes, S.M. Ceraul, S.M. Todd, K.C. Seguin, and D.E. Sonenshine. 2005. A defensin-like gene expressed in the black-legged tick, Ixodes scapularis. Med. Vet. Entomol. 19: 339-344.
Hynes, W.L. 2004. Extracellular virulence factors of group A streptococci and their regulation. (Review article). Frontiers in Bioscience. 9: 3399-3433
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Department of Biological Sciences Old Dominion University
Norfolk, VA 23529-0266
Phone: (757) 683-3595
Fax: (757) 683-5283